![]() ![]() In particular, although mitochondrial fusion processes seem to be associated with cell differentiation and senescence, 3 fission processes are mandatory during cell proliferation and, as recently stated, in apoptotic events. 1, 2 This remodeling is of great relevance in both cell life and death being a mitochondrial network involved in all the main cell activities, including proliferation, differentiation and senescence, as well as cell death by apoptosis. ![]() ![]() Mitochondria frequently undergo fission and fusion processes that regulate their morphology, number and function. Maintenance of shape and morphology is required for normal mitochondrial and cellular functions. We hypothesize that under apoptotic stimulation the recruitment of fission-associated molecules to the mitochondrial rafts could have a role in the morphogenetic changes leading to organelle fission. Accordingly, the disruption of rafts, for example, by inhibiting ceramide synthase, leads to the impairment of fission molecule recruitment to the mitochondria, reduction of mitochondrial fission and a significant reduction of apoptosis. In particular, although hFis1 was constitutively included in mitochondrial raft-like domains, dynamin-like protein 1 was recruited to these domains on CD95/Fas triggering. We found that molecules involved in mitochondrial fission processes are associated with these domains. As it was observed that lipid rafts, glycosphingolipid-enriched structures, can participate in the apoptotic cascade being recruited to the mitochondria under receptor-mediated proapoptotic stimulation, we decided to analyze the possible implication of these microdomains in mitochondrial fission. Further important mitochondrial changes have been observed in this regard: mitochondrial remodeling and fission that appear as prerequisites for the occurrence of the cell death program. Loss of mitochondrial membrane potential that follows death receptor ligation allows the release of apoptogenic factors that result in apoptosis execution. It was shown that receptor-mediated apoptosis involves a cascade of subcellular events including alterations of mitochondria. ![]()
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March 2023
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